终身大脑表现-老龄化是世界上最重要的挑战之一.pdf

1、Presented by:2024 Longevity SummitAmir Hadanny,MD,PhDChief Researcher and Head of Global Clinical OperationsAviv ScientificPhysician,Aviv ClinicsPresented by:Brain Performance for LifeDr.Amir Hadanny,MD,PhDChief Medical Officer3Aging is One of The Worlds Most Important ChallengesSource:OECD.org;Our

2、World in Data,University of Oxford,“Healthspan Is More Important Than Lifespan,So Why Dont More People Know About It?”,University of Washington St.LouisHealthspanLifespan79Challenging Period:Diseases,Fragility,Disability,Function loss etc.34EvolutionGrowth&DevelopmentAdult Reproductive YearsProtecti

3、ve AgingFrailtyShaped by Natural Selection Outside of Evolutionary Selected Period5FrailtyStem Cells and AgingGrowth&DevelopmentAdult Reproductive YearsProtective AgingFrailtyShaped by Natural Selection Outside of Evolutionary Selected Pressure6Senescence AgingSenescent Cells7Atherosclerosis and Agi

4、ngNormal vesselFatty streakFibrofatty plaqueAdvanced/vulnerable plaque8The Aging Brain8As we age,the white matter degenerates9Schwartz M,et.al.Wound Healing10 Energy(oxygen)TriggerStem cellsAngiogenesisWhat do we need for recovery of injured,non-necrotic tissue?11Oxygen Limiting Factor for Brain Act

5、ivity 12Oxygen Limiting Factor for Brain Activity12PlaceboIntervention3032343638404244PlaceboInterventionSingle taskDual taskCognitive Function 13Oxygen Limiting Factor for Brain Activity 14Energy(oxygen)TriggerStem cellsAngiogenesisWhat do we need for recovery of injured,non-necrotic tissue?15Hypox

6、ia Induced Factor-1 Alpha(HIF-1)160510152025BaselinePre HBOTHBOT#30HBOT#60Post HBOT%PBMC*N=28Shamir Medical Center(Unpublished)Hyperoxic-Hypoxic Paradox17Energy(oxygen)Trigger Stem cellsAngiogenesisWhat do we need for recovery of injured,non-necrotic tissue?180.000.100.200.300.400.500.600.70pre HBOT