如何在年老时优雅的老去.pdf

1、Presented by:2024 Longevity SummitNir Barzilai,MDDirectorInstitute for Aging Research at Albert Einstein College of MedicineNir Barzilai,M.D.Professor of Medicine and GeneticsRennert Chair for Aging ResearchDirector:Institute for Aging ResearchPI:The E-Nathan Shock CenterThe E-Glenn Center for the B

2、iology of Human AgingHow to Die Young at a Very Old AgeAviv Clinics Longevity SummitJanuary 26,2024Having a drink after therapy80706050403020100100,000 BC50,000 BC2020Over 100,000 YearsSource:Encyclopedia Britannica,Census Bureau,201078Life Expectancy at BirthThis deal got us age-related diseases,th

3、eir accumulation and bad quality of lifeWe are trying to create a new historyPREVENTIONAging has biology:This biology drives age-related diseases(Alzheimers,cancer,heart,diabetes.)Aging can be targeted so that it can bedelayed and some cases stopped and reversed.MetabolicDysregulationEpigeneticChang

4、esMitochondriaQuality controlInflammation/Declined ImmunityProteostasisSenescence(SASP)Chromosome Maintenance(DNA repair efficiency)(Telomere erosion)Stem cell dysfunctionHallmarks of AgingTargeting any of these hallmarks results in extension of heathspan and lifespan in animals.GerotherapeuticHallm

5、arks of agingPreclinical healthspanPreclinical lifespan Human healthspanHuman mortalityScore(out of 12)SGLT-2 inhibitors222 3312Metformin 2213311*Bisphosphonates2213311GLP-1 receptor agonists2203310*Rapamycin/rapalogues222309*Acarbose222309Methylene blue222309ACEi/ARB221308Dasatinib+(quercetin)22130

6、8Aspirin222107Beta blockers121037N-acetyl cysteine221005*Preclinical pointsHallmarks=3:2,3:1 Healthspan increase:2 Lifespan ITP:2,non-ITP:1 Human pointsHealthspan RCT:3,observational/open single arm:1 Mortality RCT:3,observational:1 Update on repurposed FDA-approved drugs for gerotherapeutics potent