重新思考皮肤递送：提升功能性化妆品功效的科学策略.pdf

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1、2025.7.4COSMAX R&I Rethinking Skin Delivery Scientific Strategies for Enhancing Efficacy in Functional Cosmetics1Contents1.Introduction2.Major Issues Related to Skin Delivery2Skin Delivery for Cosmetic IndustryCOVID-19&1.Introduction 国際商業 2025 4 73 1.IntroductionPenetrationPermeationResorptionDermis

2、Basal membraneVascular systemEpidermisStratum corneum(SC)Basic criteria for the in vitro assessment of dermal absorption of cosmetic ingredients,EU Scientific Committee on Consumer Safety(SCCS),SCCS/1358/10(2010)4Current Opinion in Colloid&Interface Science 17 156-165(2012)(Penetration)1.Introductio

3、nIntercellular51.IntroductionEmulsionsCosmax61.IntroductionLiquid Crystal EmulsionsKorean J.Cosmetic Sci.1(1)(2019)19-29 ()71.IntroductionNanoemulsionsJournal of Colloid and Interface Science 646(2023)311319 81.IntroductionLiposomes9Cosmax1.IntroductionSLN&NLC Colloids and Surfaces B:Biointerfaces 2

4、03(2021)111748SLN(Solid Lipid Nanoparticles)Hard Carrier Drug Drug NLC(Nanostructured Lipid Carriers)Soft Carrier SLN ()Loading Drug 102.Major Issues Related to Skin Delivery11 2.Major Issues Related to Skin Delivery1210 2-1.EfficacyStabilitySafetySensory 132-2.?Exp Dermatol 2000:9:165169 500 Da 1 n

5、m 1 0.001 nm 500 0.001 nm/=0.5 nm,r=(3 0.5)/(4)r 0.119 r 0.492 nm 0.99 nm(1 nm)1nm?142-2.ACS Applied Materials&Interfaces 2022 14(32),36331-36340 152-2.1)Iannuccelli V.et al.In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum Colloids and Surfaces B:Bio

6、interfaces 2014 122:653-661 2)Graf C.et al.Surface functionalization of silica nanoparticles supports colloidal stability in physiological media and facilitates internalization in cells Langmuir 2012 28(20):7598-613 3)Rancan F.et al.Skin penetration and cellular uptake of amorphous silica nanopartic