外泌体——科学与营销.pdf

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1、EXOSOMESUnpacking Exosomes&Exosome-Like Skincare Science vs.MarketingSkinShrinktheFaizaHussainMSc Cosmetic ScientistORIGIN OF EXOSOMESGrowth FactorsEnzymesLipidsDNAmRNACells form multivesicular bodies(MVBs)MVBs package intraluminal vesicles(ILVs)Upon physiological triggers,MVBs merge withthe cells o

2、uter membraneThese ILVs are then released outside the cellnow as extracellular vesicles(EVs)A subtype of EVs are tiny exosomes(30-150nm)Only released exosomes can interact with othercells.SkinShrinktheSkinShrinktheFaizaHussainMSc Cosmetic ScientistEXOSOMESThe term exosome emerged in 1981 Natures del

3、ivery system of nano-sizedbiological cargo.Carriers of proteins(growth factors),RNAs andfats that cells use to communicate withneighbouring cells.Specialise in repair signals(collagen),antioxidant delivery or inflammation control.SkinShrinktheSkinShrinktheSkinShrinktheFirst discovered in the 1980s(r

4、eticulocytes)ascellular waste carriers.1990s found to carry immune bio-communicatorsignals.Mid 2000s rise in MSC-derived exosomes andembryonic stem cell vesicles regenerative studies.20122016 South Koreas regulatory flexibility,patents filed 2012 and commercial products.Sourced from diverse cells i.

5、e.human etc.FIRST DISCOVERYSkinShrinktheReticulocytes ExosomesMesenchymal Stem CellsSkinShrinktheSkinShrinktheSkinShrinktheExosomes go beyond the surface-working at the cellular level to regenerate,repair andrejuvenate skin.KEY CLAIMS Collagen stimulation:Kim et al.,Stem Cell Res Ther,2020 Barrier r

6、epair and microbiome:Choi et al.,J Cosmet Dermatol,2022 Post-procedure recovery:RF,microneedling,laserWHY EXOSOMES MATTER INSKINCARESkinShrinktheSkinShrinktheSkinShrinktheSkinShrinktheMARKET EXPANSION:GLOBAL®IONAL2024:$280.6M 2033:$640.3M(9.6%CAGR)Global Growth InsightsEurope(UK,Germany,France Le