深入探讨造血干细胞移植治疗多发性硬化症的潜力.pdf

1、Deep dive into the potential of Hematopoietic Stem Cell Transplant in treating Multiple SclerosisAmanda L.Piquet,MDAssociate Professor of NeurologyDirector,Autoimmune Neurology ProgramNeuroimmunology,Neuroinfectious Disease and Neurohospitalist SectionsUniversity of Colorado School of MedicineObject

2、ivesDescribe hematopoietic stem cell transplant what is it?Background and history of transplant in MSCurrent data in stem cell transplant for MS where are we now?Future research where are we going?What is hematopoietic stem cell transplant?What it is NOT?Medical Tourism(especially in foreign countri

3、es)“Infusion”of stem cells into spinal fluid or through and IV through“stem cell clinics”Swart JF,Delemarre EM,van Wijk F,Boelens JJ,Kuball J,van Laar JM,Wulffraat NM.Haematopoietic stem cell transplantation for autoimmune diseases.Nat Rev Rheumatol.2017.Hematopoietic stem cell transplant(HSCT)invol

4、ves administering healthy hematopoietic stem cells(either self or donor)to patients with dysfunctional immune system with the positional to induce long-term,drug-free and symptom-free remission in several refractory autoimmune rheumatic disease.Systemic sclerosis is the first autoimmune disease for

5、which HSCT has been shown in a randomized,controlled trial,to be associated with transplant-related mortality in the first year,but a significant long-term,event-free survival benefit afterwards.Stem Cell Therapies:Medical TourismUnapproved stem cell therapies can be harmful and may be illegal and u

6、nprovenhttps:/www.fda.gov/consumers/consumer-updates/fda-warns-about-stem-cell-therapiesStem Cell Therapies:Medical TourismUnapproved stem cell therapies can be harmful and may be illegal and unprovenhttps:/www.fda.gov/consumers/consumer-updates/fda-warns-about-stem-cell-therapiesStem Cell Therapies