长寿革命：我们可以改变衰老的速度、基因还是生活方式导致了衰老.pdf

1、Presented by:2024 Longevity SummitEric Verdin,MDPresident and CEOBuck Institute for Research on AgingEric Verdin,CEO/President Buck Institute for Research on AgingThe Longevity RevolutionBreakthrough#1We can change the rate of aging4Modulation of Lifespan by Calorie RestrictionWe have identified con

2、served aging pathwaysExtendinghumanhealthspan:the futureSource:Varied/Axon Capital Partners research.In some cases these are median healthspan increases,and vary by stratificationNR (precursor to NMN&NAD)+5%Metformin+6%Acarbose+22%Rapamycin+26%Senescent cell clearance+35%FGF-21+36%GHRHKO+46%Axon Cap

3、ital Partners LtdThere are over 100 interventions that can extend the healthspan of a mouse.A number are in the clinic for humans but most have not yet been pursued as targets for drug development.Human Human TrialTrial ProgressProgressPhase IFDA Approved(Diabetes)FDA Approved(Diabetes)FDA Approved(

4、Organ Transplants)Phase IIPhase IIIPre-clinical researchBreakthrough#2Aging is the largest risk factor for non communicable diseasesBreakthrough#3Reinventing MedicineReinventing MedicineReinventing MedicineBreakthrough#4What drives aging:genes or lifestyle?93%non-genetic7%geneticGenetics,2018,210:11

5、09112416The 5 Pillars of AgingSome take home messagesWhat can I do today to maximize my healthspan and lifespan?We have a shorter life expectancy than almost all other high-income countries.The US spends the most in the world on healthcare yet ranks only 31st in life expectancy.Life Expectancy In Th

6、e USLife Expectancy In The US21Combined data from the Nurses Health Study&the Health Professionals Follow-up StudyThese studies followed 123,000 people over a 34-year periodData obtained through validated interviews,questionnaires,and self-reporting22A Prescription for adding 12+