在安大略省和加拿大推进随机对照试验 （RCT）.pptx

1、,Advancing randomized controlled trials in Ontario and Canada,P.J.Devereaux,MD,PhDNominated Principal Applicant of ACT ConsortiumCEO and Scientific Director of the World Health Research Trust Associate Deputy Director of the Population Health Research Institute,Disclosures,Based on study questions I

2、 originated and grants I wroteI have received grants from Abbott Diagnostics,AOP,AstraZeneca,Bayer,Boehringer Ingelheim,Bristol-Myers Squibb,Cloud DX,Covidien,Octapharma,Philips Healthcare,Roche Diagnostics,Roche,Siemens,Smith and Nephew,Stryker,TrimedicI have participated in advisory boarding meeti

3、ng GlaxoSmithKline,Bayer,Quidel Canada,Trimedic expert panel meeting AstraZeneca,BI,RocheInternational meetings AOPI have undertaken consultancy work forAstra Zeneca,Abbott Diagnostics,2,Goals of presentation,A child highlighted our problemAccelerated Clinical Trials(ACT)ConsortiumUpdate on ACTs act

4、ivities in the last yearFuture directions,A child highlights our problem,2 yr old boy diagnosed with metastatic brain cancer in OntarioFamily told he had months to live as there were no treatment optionsRemortgaged house brought son to NY and enrolled him in RCTClinical trial saved his life;he is no

5、w 18 years of ageEveryday trials like this one do not come to Canada or limited numbers of participants are assigned to Canada because our trials system is so inefficientMoral imperative to improve ecosystem for doing RCTs in Canada to bring more opportunities to Canadians to participate in trials,A

6、ccelerating Clinical Trials(ACT)Canada,Funded by CIHR($39 Million)to improve ecosystem for conducting RCTs in Canada,Central guiding principle,Our activities will accelerate,optimize,and facilitate the conduct,implementation,and results translation from high-quality,high-impact RCTs to improve healt