从数据到发现：GenAI 如何改变生物信息学.pdf

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1、10.12.2024From Data to Discovery:How GenAI is Changing BioinformaticsIris Wing To Lam Co-founder and CEO,Genie TechBioWorld Summit AI Qatar2AgendaWhy Bioinformatics(BFX)?My personal experienceApplications of GenAI in BFXFuture Potential of GenAI in BFXConclusion1.2.3.4.5.3AgendaWhy Bioinformatics(BF

2、X)?My personal experienceApplications of GenAI in BFXOutlook and Conclusion1.2.3.4.4Bioinformatics is an interdisciplinary field that combines biology,computer science,and mathematics to analyze and interpret complex biological data.Why Bioinformatics(BFX)?5Think of bioinformatics as the Google Maps

3、 for biological research it helps scientists navigate through vast amounts of data to find their destination:understanding diseases.Why Bioinformatics(BFX)?Understanding Virus Structure and FunctionBy utilizing genomic sequencing,researchers were able to identify viral genes and proteins that could

4、serve as targets for vaccine development.6Why Bioinformatics(BFX)?Wacharapluesadee,S.,Tan,C.W.,Maneeorn,P.et al.Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia.Nat Commun 12,972(2021).https:/doi.org/10.1038/s41467-021-21240-1Identifying Immune Respon

5、sesTranscriptomics and proteomics provided insights into how the immune system responds to vaccination.7Why Bioinformatics(BFX)?Wendisch D,Dietrich O,Mari T,et al.SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.Cell.2021;184(26):6243-6261.e27.doi:10.1016/j.cell.2021.

6、11.033Accelerating Antigen Discovery Viral genome sequences,transcriptomic and proteomic data allowed researchers to identify specific antigens from the SARS-CoV-2 virus that could elicit a strong immune response.8Why Bioinformatics(BFX)?Ong,E.Z.,Yee,J.X.,Ooi,J.S.G.et al.Immune gene expression analy