From CPET to Wave Mechanics—Decoding Pulmonary Vascular Pathobiology.pptx

1、From CPET to Wave Mechanics Decoding Pulmonary Vascular Pathobiology,Farhan Raza MDAssociate ProfessorPulmonary Hypertension,Heart failure and transplantDirector Invasive Cardiopulmonary Exercise Test Laboratory,VITALITY-Vericiguat,PASSION-Tadalafil,RELAX-Sildenafil,SERENADE-Macitentan,PVR-guided tr

2、ials have failed in PH-HFpEF,VITALITY-Vericiguat,PASSION-Tadalafil,RELAX-Sildenafil,SERENADE-Macitentan,PVR-guided trials have failed in PH-HFpEF,Disease Pathobiology,Treatment,A test to precisely quantify the disease,Pulmonary vascular pathobiology of PH-left heart disease.,Pulmonary vascular resis

3、tance:PVR is not enough!CPET and Wave Mechanics decode the complexity,1.,2.,3.,1.Boehm,Mario,and Ralph T.Schermuly.Pulmonary Arterial Hypertension.Encyclopedia of Molecular Pharmacology.Cham:Springer International Publishing,2022.1328-1336.2.Fayyaz,Ahmed U.,et al.Global pulmonary vascular remodeling

4、 in pulmonary hypertension associated with heart failure and preserved or reduced ejection fraction.Circulation137.17(2018):1796-1810.3.Nossent EJ,Smits JA,Seegers C,Meijboom LJ,Boonstra A,Aman J,De Man FS,Bogaard HJ,Radonic T,Dorfmller P,Noordegraaf AV.Clinical correlates of a nonplexiform vasculop

5、athy in patients with a diagnosis of idiopathic pulmonary arterial hypertension.Chest.2024 Jul 1;166(1):190-200.,Pulmonary Artery,Pulmonary Vein,HFpEF,1.PVR is not enough!,RV,LV,1.Boehm,Mario,and Ralph T.Schermuly.Pulmonary Arterial Hypertension.Encyclopedia of Molecular Pharmacology.Cham:Springer I

6、nternational Publishing,2022.1328-1336.2.Fayyaz,Ahmed U.,et al.Global pulmonary vascular remodeling in pulmonary hypertension associated with heart failure and preserved or reduced ejection fraction.Circulation137.17(2018):1796-1810.3.Nossent EJ,Smits JA,Seegers C,Meijboom LJ,Boonstra A,Aman J,De Ma