探索肾细胞癌疾病谱中与健康相关的生活质量：概念领域分析.pdf

1、Exploring Health-Related Quality of Life Across Renal Cell Carcinoma:A Conceptual Domain Analysis.Koral Shah,MDCity of Hope Comprehensive Cancer CenterBACKGROUND=FKSI-23 Evaluating treatment outcomes requires health-related quality of life(HRQOL)and patient-reported outcomes measures(PROMs)FKSI-19,E

2、ORTC QLQ-C30,and EQ-5D may not fully reflect the experiences of patients with RCC Led to a tailored,new HRQOL measure(Bergerot et al.,J Clin Oncol 2025)Functional Assessment of Cancer TherapyKidney Symptom Index OBJECTIVE Explore the differences in HRQOL priorities between patients with localized an

3、d metastatic RCCo This is new data from a secondary analysis of the data that led to the creation of FKSI-23METHODS Calculated the average number of items rated as relevant within each domain Used ANOVA with partial eta squared()to estimate effect sizeDisease-related symptoms-physical(DRS-P)Disease-

4、related symptoms-emotional(DRS-E)Treatment side effects(TSE)Function&well-being(FWB)RESULTSCharacteristicsLocalized(n=83)Metastatic(n=117)Age M(SD)60(26-92)64(32-88)Sex N(%)Male Female51(61.4)32(38.6)83(70.9)34(29.1)Histology N(%)Clear Cell Papillary Chromophobe78(94.0)4(4.8)1(1.2)105(89.7)7(6.0)5(4

5、.3)Treatment N(%)Immunotherapy Targeted Therapy Combination No Treatment50(60.2)0(0.0)0(0.0)33(39.8)41(35.0)35(29.9)23(19.7)18(15.4)Patient CharacteristicsLocalized RCCMetastatic RCCFKSI-19FKSI-19QLQ C-30QLQ C-30EQ-5D RESULTSPercentagePercentagePatients Who Found Items RelevantRelevant=Rated by 66%o

6、f patientsRESULTSDisease-related symptoms physicalDisease-related symptoms emotionalTreatment side effectsFunction&well-beingMean Relevance Score of Domains by Disease Stage The relevance of physical symptoms and treatment side effects amon