肾癌个性化疫苗：从概念到临床的历程.pdf

1、Personalized Vaccines in Kidney Cancer:A Journey from Concept to ClinicDavid A.Braun,MD,PhDAssistant Professor|Louis Goodman and Alfred Goodman Yale ScholarYale Cancer Center|Yale School of MedicineYochum,Targeted Oncology.2025Yochum,Targeted Oncology.2025Yochum,Targeted Oncology.2025Rationale Neoan

2、tigens are targets of effective anti-tumor T cell immunity Personalized cancer vaccines targeting neoantigens can generate T cell responses(e.g.melanoma,GBM,pancreatic cancer)Renal cell carcinoma(RCC)is a historically and contemporarily immunogenic tumor with a modest mutation burden There is an ong

3、oing need for improved adjuvant therapies for RCCRationale Neoantigens are targets of effective anti-tumor T cell immunity Personalized cancer vaccines targeting neoantigens can generate T cell responses(e.g.melanoma,GBM,pancreatic cancer)Renal cell carcinoma(RCC)is a historically and contemporarily

4、 immunogenic tumor with a modest mutation burden There is an ongoing need for improved adjuvant therapies for RCCCan we design an immunologically effective personalized neoantigen vaccine in RCC?A personalized neoantigen vaccine for clear cell RCCEXCLUSION ZONEBraun,Nature.2025Trial overviewA person

5、alized neoantigen vaccine for clear cell RCCEXCLUSION ZONEBraun,Nature.2025Trial overviewSuccessful vaccine manufacturing for all patientsNeoantigen vaccination is highly immunogenic in RCCBraun,Nature.2025Neoantigen vaccination is highly immunogenic in RCCEx vivo T cell response in all patientsBrau

6、n,Nature.2025Neoantigen vaccination is highly immunogenic in RCCEx vivo T cell response in all patientsDeconvolution of immunogenic neoantigensBraun,Nature.2025Driver mutations elicit strong immune responseEXCLUSION ZONEBraun,Nature.2025Strong response against VHLmut peptideDrive