深度学习对创建新型生物功能效应子的影响.pdf

1、5th National Big Data Health Science ConferenceColumbia,South CarolinaFebruary 3,2024The Impact of Deep Learning for Creating Novel Effectors of Biological FunctionsBIGDATACharles Darwin(1809-1882)Transmutation of Species“Survival of the Fittest”Charles Darwin Natural SelectionThe concept of natural

2、 selection was originally developed in the absence of a valid theory of heredity;at the time of Darwins writing,nothing was known of modern genetics.The concept of fitness is central to natural selection.In broad terms,individuals that are more fit have better potential for survival,as in the well-k

3、nown phrase survival of the fittest.Proposed in parallel by Alfred Russell WallaceMendel demonstrated that the inheritance of certain traits in pea plants follows particular patterns,now referred to as the laws of Mendelian inheritance.“Particulate”nature of inheritance of traits.The laws formed the

4、 foundation of the modern science of geneticsGregor Mendel(1822 1884)British-born geneticist,protein chemist.and evolutionary biologist generally credited with a central role in the development of neo-Darwinian thinking.Genetic(gene)basis of transmutation of speciesMutations of genes give rise to“tr

5、ansmutation of species”by changing the structure of the encoded gene productJ.B.S.Haldane(1892 1964)Francis Crick in 1957In February 1953,Watson and Crick completed their model,which is now accepted as the first correct model of the double-helix of DNA.On 28 February 1953 Crick interrupted patrons l

6、unchtime at The Eagle Pub in Cambridge to announce that he and Watson had discovered the secret of lifeOne strand templates the second strandFrancis CrickJames WatsonRosalind Franklin“Structural Biology”using molecular structures to understand biologyFrancis Crick in 1957Paradigm of Molecular Biolog