掌握神经酰胺新时代：Sphingo'Hair™ Drypure™ 为您解锁完整的神经酰胺解决方案.pdf

1、Mastering the new era of Ceramides:Unlocking complete ceramide solution with SphingoHAIR Drypure Todays speakerDr.Simon KimMaster of Biotechnology,Ajou UniversityResearch and Technology ManagerCroda Korea LimitedCroda Korea LimitedSkin barrier structureSource:(1)Baker,P.;Huang,C.;Radi,R.;Moll,S.B.;J

2、ules,E.;Arbiser,J.L.Skin Barrier Function:The Interplay of Physical,Chemical,and Immunologic Properties.Cells 2023,12,2745.Stratum corneum Sphingolipids40-50%mainly ceramidesFree fatty acids10-25%Cholesterol20-25%WaterLipidsCytoplasmic membraneIntercellular spaceCytoplasmThe stratum corneum(SC),the

3、outermost section of the epidermis,is made of:Corneocytes(flat nucleus free keratinocytes)acts as bricks.Hydration regulation and physical shield against UV radiation1.A lipid matrix(multilayer lamellae),surrounding corneocytes,acting as cement.Protection against microbes and free radicals1.Disrupti

4、on of physical barrier:Water loss Penetration of allergens,microbes,chemicals Increased UV light skin penetrationDisruption of chemical barrier maintaining an acidic pH:Dehydration DysbiosisDisruption of microbiological barrier:Dysbiosis Inflammation InfectionsDisrupted skin barrierEnvironmental fac

5、tors,UV light and chronological ageing impact skin ceramides.Changes in the structure,quantity and proportions of ceramides are associated with accelerated ageing and skin conditions,such as atopic dermatitis or psoriasis.Dryness itchiness loss of elasticity inflammation accelerated ageing atopic sk

6、in conditionCeramides are the most abundant SC lipids with hundreds of structures,present in different quantities and distinct functions.Solution -CeramidesNPAPOPEOHNHAHOHEODSNdS(NG)ADSEOSNSASOSEOPCeramideNPMostabundantSCSCCeramidesCeramides(1)(1)(1)Moore DJ,Rawlings AV.The chemistry,function and(pa