11.ดร.พิมพ์ลภัส ลี้กิจเจริญผล_Antibiotic resistance_What is the alternative.pdf

1、Technical University of Denmark219-01-2026Antibiotic Resistance:What is the Alternative?Pimlapas Leekitcharoenphon(Shinny)Senior Researcher/Associate ProfessorResearch Group for Genomic EpidemiologyTechnical University of Denmark(DTU)pilefood.dtu.dk16thJanuary 2026Technical University of Denmark319-

2、01-2026 Famine War Infectious diseasesTechnical University of Denmark4AMR 1.5 10 million/yearNaghavi,Mohsen et al.Global burden of bacterial antimicrobial resistance 19902021:a systematic analysis with forecasts to 2050.The Lancet.20242050Technical University of Denmark5Antibiotic:PenicillinAlexande

3、r Fleming(18811955)Penicillium notatumPetri dish in 1928Staphylococcus aureusTechnical University of DenmarkAntimirobialResistance(AMR)“Its not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them.there is the danger that

4、 the ignorant man may easily under-dose himself and,by exposing his microbes to non-lethal quantities of the drug,make them resistant.”(A.Fleming,Penicillin,Nobel Lecture,11 December 1945)6Technical University of DenmarkTahmasebi,H.;Arjmand,N.;Monemi,M.;Babaeizad,A.;Alibabaei,F.;Alibabaei,N.;Bahar,A

5、.;Oksenych,V.;Eslami,M.From Cure to Crisis:Understanding the Evolution of Antibiotic-Resistant Bacteria in Human Microbiota.Biomolecules 2025,15,93.Technical University of DenmarkWhat are the solutions so far?Reduction of antibiotic usageNew drugs and treatmentAlternatives?AMR surveillance-To know w

6、here we are 819-01-2026Technical University of Denmark919-01-2026How can we detect AMR?Technical University of DenmarkHasman et al,2014Technical University of Denmark11Resistant genesResistant findingUnknown seqBLAST/KMAResistant profileResFinderTechnical University of Denmark12https:/cge.food.dtu.d