RSV-Maternal-and-infant-programs-–-lessons-and-challenges-Dr-Archana-Koirala-9th-AIF-2025.pdf

1、Dr Archana KoiralaRSV maternal and infant programs lessons and challenges08:40Paediatric Infectious Diseases SpecialistNational Centre for Immunisation Research and SurveillanceRSV maternal/infant programs:lessons and challengesDr Archana KoiralaPaediatric Infectious Diseases PhysicianNational Centr

2、e for Immunisation Research and Surveillance,The Childrens Hospital at Westmead,Nepean HospitalClinical Lecturer,The University of SydneyWhy is RSV so important?https:/www.kidshealth.org.nz/bronchiolitisRespiratory Syncytial Virus(RSV)Affects the upper and lower respiratory tract and is the leading

3、cause of bronchiolitisMucus buildup and thickened respiratory wall of the small infant bronchiolesLarge burden of disease and hospitalisation in infants for assistance with ventilation and feedingRSV burden affects most infants by the age of 2 years2%(1 in 50 children hospitalised by 12 months of ag

4、eBurden is higher in Aboriginal and Torres Strait Islander infants RSV:Risk factors for hospitalisationVartiainen 2023:https:/ most children who are hospitalised with RSV are born healthy,at term Up to 70-80%of hospitalised children 24 months are otherwise healthyAnnual global pediatric RSV disease

5、burden(5 years of age)LEADING CAUSE OF SEVERE RESPIRATORY INFECTION33,000,000episodes3.6 millionhospitalizationsReference:Li Y,et al.Lancet 2022.6 months20%6 months to 5 years80%6 months to 5 years61%LEADING CAUSE OF PEDIATRIC HOSPITALIZATIONIMPORTANT CAUSE OF PEDIATRIC MORTALITY 6 months39%6 months

6、 to 5 years54%6 months46%101,000deathsTOTAL GLOBAL CHILD MORTALITY DUE TO RSV3.6%6 MONTHS 2.3%5 YEARS Nearly half of RSV deaths are before 6 months of ageOriginal slide developed by PATH,UMC Utrecht,and the World Health Organization.Last updated:December 2023Long term effects of RSV illnessAsthmaNon