Integration of the PAC with PV Loop Measurement.pptx

1、An Integrated Pressure-Volume Loop Pulmonary Artery Catheter,M.Imran Aslam,MDAssistant Professor of Medicine,Tufts Medical CenterInterventional/Advanced Heart Failure&Transplant CardiologyDirector,Acute Mechanical Circulatory Support Director,Robert Kung Interventional Heart Failure Clinical and Res

2、earch Fellowship Program,Disclosure(s),No relevant financial disclosuresInternational Patent Application PCT/US2024/033286,Traditional Acquisition of PV Loop Data,Pigtail catheter with sequentially placed electrodes measuring blood conductance by summation of segments,converting into a volume;requir

3、es catheter to be placed in a longitudinal axis As conductance is unable to differentiate between blood and muscle component,a parallel conductance offset factor(Vp)is required to convert signal into volume;(requires injection of hypertonic saline,altering conductivity of blood or obtaining accurate

4、 end-diastolic ventricular volume by imaging)Calibration,positioning can be tedious/time consuming,and requires administration of hypertonic saline/concomitant imaging for accurate data,Myocardium,Blood,Pigtail Conductance Catheter,1,2,3,4,5,Summation of segment volumes to obtain chamber volume,Righ

5、t Ventricle(RV)apex,Admittance Method for Data Acquisition,What is Admittance?Measures admittance magnitude and phase angle1-3 of ventricular blood and muscle,Following removal of myocardial component,isolated blood conductance is then converted to volume1-3No need to calculate parallel conductance(

6、i.e.no hypertonic saline bolus required)Admittance is validated in small/large animals,and has been simultaneously compared to conductance3-7,Admittance isolates blood component in the signalProviding accurate volume determination in the human right ventricle(RV),with significantly lower coefficient