Heart Failure Syndromes & Hemodynamic Aberrancies.pptx

1、Heart Failure Syndromes and Hemodynamic Aberrancies,Mandeep R.Mehra,MBBS,MSc,FRCP(London)The William Harvey Distinguished Chair in Advanced Cardiovascular MedicineProfessor of Medicine,Harvard Medical School,Disclosures:Consultant for Abbott,Natera,Paragonix,Moderna,NupulseCV,Fineheart,Transmedics,L

2、eviticus,Cadrenal Therapeutics,Second Heart Assist,Houston B,Shah K,Mehra M,Tedford R.JHLT.2017;36(7):701-707,Changing Epidemiology of Late Deaths with LVAD Therapy,Mehra MR,Goldstein DJ,Cleveland JC,et al.JAMA.2022;328(12):1233-1242,JAMA.2022;328:1233-1242.,JACC Heart Fail.2022;10:470-481.,Time Dep

3、endent Risk of Heart Failure Hospitalization and Prognosis in MOMENTUM 3,Prognosis of Heart Failure Hospitalization,Vidula et al Mehra.JACC Heart Fail.2022;10(7):470-481,Classification Variability of HF Syndromes,Events presented as Percent of Subjects(n/N),Events,Events per 100 patient years(95%CI)

4、,Vidula et al Mehra.JACC Heart Fail.2022;10(7):470-481,Boulet J,Nayak A,Mehra MR.J Card Fail.2022;28(12):1738-1740,Boulet J,Nayak A,Mehra MR.J Card Fail.2022;28(12):1738-1740,Houston B,Shah K,Mehra M,Tedford R.JHLT.2017;36(7):701-707,Mostly an Early Event?,Definitions Matter,Circ Heart Fail.2023;16(

5、6):e009960.,ASAIO J.2024;70:641-650.,Circ Heart Fail.2019;12(4):e006067.,Front Cardiovasc Med.2023 Jan 9;9:1094796.,S/D velocity 5=Significant AR,Severe AR(S/D=2.3),No AR(S/D 5,Artif Organs.2020;44(8):883-891.,J Heart Lung Transplant.2010;29:1321-9.,Boulet J,Nayak A,Mehra MR.J Card Fail.2022;28(12):

6、1738-1740,Venous Capacitance and IVCCentral Modulators of Hemodynamic Congestion,Boulet J,Nayak A,Mehra MR.J Card Fail.2022;28(12):1738-1740,Inflow Obstruction,Take Home Points,Right Heart Failure is mostly an Early Event and declines in mo