Hemodynamic Phenotyping to Guide HFpEF Therapies.pptx

1、CHICAGO HEMODYNAMIC FORUM 2025,Sanjiv J.Shah,MDStone Endowed Professor of MedicineDirector of Research,Bluhm Cardiovascular InstituteDivision of Cardiology,Department of MedicineDirector,Center for Deep Phenotyping and Precision Therapeutics,Institute for Augmented Intelligence in MedicineNorthweste

2、rn University Feinberg School of Medicinesanjiv.shahnorthwestern.edu,Hemodynamic Phenotyping to Guide HFpEF Therapies,Disclosures,Research funding:NIH U54 HL160273,X01 HL169712,R01 HL140731,R01 HL149423AHA#24SFRNPCN1291224 AstraZeneca,Boston Scientific,Corvia,Pfizer,TempusConsulting/advisory board/s

3、teering committee:35Pharma,Abbott,Alleviant,AstraZeneca,Amgen,Axon Therapies,BaroPace,Bayer,Boehringer-Ingelheim,Boston Scientific,BMS,Corvia,Cytokinetics,Diastol Therapeutics,Edgewise,Edwards,Ensho Health,Eidos,Gordian,Imara,Impulse Dynamics,Intellia,Ionis,Lilly,Merck,Metabolic Flux,Novartis,Novo N

4、ordisk,OrbiMed,Pfizer,Prothena,Regeneron,Rivus,SalubrisBio,Sardocor,Secretome,Shifamed,Tectonic,Tenax,Tenaya,Ultromics,HFpEF therapies in 2025:One size fits all?,HFpEF clinical trials until 2020,THEN:Cumulative hazard curves for HF hospitalization or CV deathACE-I,ARB,MRA,ARNI,CHARM-Preserved,I-PRES

5、ERVE,TOPCAT,PEP-CHF,PARAGON-HF,HFpEF clinical trials then vs.now,NOW!SGLT2iGLP1-RA nsMRAGDMT for HFpEF!,EMPEROR-Preserved,TOPCAT,PEP-CHF,PARAGON-HF,DELIVER,FINEARTS-HF,STEP-HFpEF+STEP-HFpEF-DM(pooled),Now:4 pillars of GDMT for HFpEF,Kosiborod M,et al.NEJM 2023;Kosiborod,et al.NEJM 2024;Packer M,et a

6、l.NEJM 2024;Solomon SD,et al.NEJM 2020;Mentz RJ,et al.JACC 2023;Pieske B,et al.JAMA 2021;Pitt B,et al.NEJM 2014;Pfeffer M,et al.Circulation 2015;Solomon SD,et al.NEJM 2024;Anker SD,et al.NEJM 2021;Solomon SD,et al.NEJM 2022;Nassif M,et al.Nat Med 2021,HFpEF therapeutics:Are we done?,Cumulative incid