WSPH Challenge Accepted Optimizing PH Risk Scoring with Hemodynamics.pptx

1、WSPH Challenge Accepted:Optimizing PH Risk Scoring with Hemodynamics,Thomas Cascino,MD,MScAssistant Professor of Medicine,TomCascinoMD,Disclosures,Grant/Research SupportNational Institutes of Health/NHLBI(K23 HL1781910)(1R01HL167816)Johnson&Johnson to my institutionSpeaker Honoraria:AbbottConsulting

2、:CareDx,Impulse Dynamics,Johnson&Johnson,&Merk,Inc.,Clinically focused talk:RV-PA coupling is not currently practical,Learning Objectives,Review the current state of multiparametric risk assessment in PH,Summarize the key evidence linking hemodynamic parameters to outcomes in PAH,including their inc

3、remental value in established risk models,Discuss emerging opportunities,challenges,and future directions for integrating hemodynamic data into risk stratification,Right heart catheterization is the gold standard for diagnosing and classifying PH,Kovacs,G.ERJ.2024;Humbert,M.EHJ.2022;Cascino,TM et al

4、.J Card Fail,2025,7th WSPH diagnostic algorithm for PH,Hemodynamic classification of PH,Suggested assessment and timing for follow-up with PAH,and provides important prognostic information at the time of diagnosis and follow-up,Chin KM et al.Eur Respir J.2024,Treatment algorithm from the 7th WSPH,Ri

5、sk-based,goal-oriented treatment approach,Used to classify risk from low to high risk based on one-year risk of death,Dardi,F.Eur Res J.2025,14,6,8,4 to 6,4 to 6,4,6,All have been validated in incident and prevalent cohorts and for time to clinical worsening and mortality,Overview of risk assessment

6、 tools,Dardi,F.Eur Res J.2025,Multiparametric risk assessment will be superior to any variable alone,Benza,R.Chest.2021,C statistic 0.73(95%CI 0.71-0.75),C statistic 0.70(95%CI 0.68-0.72),Multiparametric risk assessment will be superior to any variable alone,Hemodynamics improve stratification sligh