借助 AWS 加速大规模药物发现研发.pdf

1、 2025,Amazon Web Services,Inc.or its affiliates.All rights reserved.2025,Amazon Web Services,Inc.or its affiliates.All rights reserved.CMP345Accelerate Drug Discovery R&D at Scale with AWSMarissa E Powers PhD(she/her)Solutions ArchitectHPC Life SciencesShreya Pandita(she/her)Solutions Architect Heal

2、thcare&Life Sciences 2025,Amazon Web Services,Inc.or its affiliates.All rights reserved.Common challengesCustomer case studiesWhiteboarding!TodayWhat is your current role?What scientific applications or use cases are you working with today?What do you most want to learn about today?2025,Amazon Web S

3、ervices,Inc.or its affiliates.All rights reserved.Fundamental building blocks for HPCStorageBucket withobjectsFile systemElastic Block Store VolumesComputeInstanceContainerLambda functionAuto Scaling groupNetworkElastic Fabric AdapterAvailability ZoneVPCAvailability ZoneRegionVisualizationAmazon DCV

4、Amazon WorkSpaces FamilyResearch and Engineering Studio 2025,Amazon Web Services,Inc.or its affiliates.All rights reserved.The Drug Development Challenge$6B R&D per drug|12-15 years per drug|10%success rateIf we reduce cycle times10-20%Drug Discovery5-10%Clinical DevelopmentWe can reduce R&D Develop

5、ment Costs$30-60M/drugAnd increase earlier revenue realization for$50B Company$375M-750M/yr.0.75%to 1.5%of overall revenue 2025,Amazon Web Services,Inc.or its affiliates.All rights reserved.Hit IdentificationLead OptimizationTarget IdentificationGenomicsStructure-based discoveryImaging and digital p

6、athologyAI-driven drug discoveryVirtual screeningComputational ChemistryData managementTarget IdentificationHit IdentificationLead Optimization Pre-clinical TestingClinical TestingDrug Review and Approval Research Research&Discovery&Discovery 1-2 years 4-7 years 1-4 years 2025,Amazon Web Services,In