治疗阿尔茨海默病和痴呆症的新药.pdf

1、Newer Treatments for Alzheimers Disease and DementiaJ.Mark Ruscin,Pharm.D.,FCCPProfessor,Dept of Pharmacy PracticeSIUE School of PharmacyMy Background and Perspective Faculty member at SIUE School of Pharmacy since 2008 Previously at Univ of CO School of Pharmacy and Center on Aging(1995 2008)Teachi

2、ng,clinical service,and research interests revolve around the care of older adults John D Ruscin 1927-2024SCIENCE&MEDICINEFDA OKs Alzheimers Disease Treatment:Health Officials say drug is not a cure but that it will offer relief from symptoms for some.It is expected to cost about$1,500 a year.By MAR

3、LENE CIMONSSept.10,1993 12 AM PTTIMES STAFF WRITERWASHINGTON The Food and Drug Administration on Thursday approved the first drug for the treatment of Alzheimers disease,a debilitating brain ailment that robs millions of elderly people of their memory,independence and dignity.https:/ brief look at t

4、he history of FDA drug approvals for Alzheimers Disease(AD)Isoxuprine,cyclandelate,dipyridamole(not FDA approved)Tacrine-First treatment FDA approved for AD 1993Donepezil -FDA approved in 12/1996Rivastigmine-FDA approved in 4/2000Galantamine-FDA approved in 2/2001Memantine-FDA approved in 10/2003Adu

5、canumab*accelerated FDA approval Jan 2021 *(Off market as of Jan 2024)Lecanemab FDA approved 7/2023Donanemab FDA approved 7/2024Benzgalantamine FDA approved 7/2024Cummings J,et al.Alzheimers disease drug development pipeline 2024.Alzheimers Dement.2024;10:e12465“New”Medications Donepezil patch(Adlar

6、ity)5mg or 10mg systems Transdermal administration once weekly(apply to upper back)FDA approved 3/22-acetylcholinesterase inhibitor indicated for the treatment of mild,moderate,and severe dementia of the Alzheimers type Must be refrigerated Clinical implications Avoids first pass metabolism Lower ri