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诺为泰(Novotech):2024 胃癌:全球临床试验概况报告(英文版)(21页).pdf

上传人: Kell****reet 编号:615148 2024-12-29 21页 2.35MB

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1、novotech-AUGUST 12,2024Gastric Cancer-Global Clinical Trial Landscape(2024)GC is the 5th most diagnosed cancer and the 5th leading cause of cancer mortality,character-ized by uncon-trolled cell growth in the stomach wallThe content of this publication is proprietary to Novotech Health Holdings.No pa

2、rt of this publication may be reproduced,distributed,or transmitted in any form or by any means,including photocopying,recording,or other electronic or mechanical methods,without the prior written permission of Novotech except in the case of quotations embodied in reviews and non-commercial uses.Ple

3、ase note that this copyright statement applies specifically to this publication and its content and does not extend to other materials or intellectual property owned by Novotech.Any unauthorized reproduction or distribution of this publication or any portion thereof may result in legal action taken

4、by Novotech to protect its rights.For permissions or inquiries,please contact:communicationsnovotech-#DYK Did youknow?In the Asia-Pacific region,China reported a relatively higher incidence of GC casesThe United States reported the highest number of GC cases in North AmericaIn Europe,Germany recorde

5、d a relatively higher incidence of GCIn ROW,Brazil had the highest incidence of GCMarketed drugs emphasize antibody therapies targeting HER2(e.g.,trastuzum-ab)and immune checkpoint inhibitors like PD-1/PD-L1 inhibi-tors(e.g.,pembroli-zumab,nivolumab)Phase III trials are advancing immunotherapy optio

6、ns and antibody-drug conjugates(e.g.,trastuzumab emtan-sine),showing promis-ing advancement in GC treatmentGASTRIC CANCERTRIAL CONTRIBUTIONSThe U.S.and Asia-Pacific region show similar recruitment ratesGASTRIC CANCER(GC)GLOBAL CLINICAL TRIAL LANDSCAPE(2024)5%ROW55%NORTH AMERICA&EUROPE45%ASIA-PACIFIC

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本文主要介绍了全球胃癌(GC)的流行病学、标准治疗、全球临床试验景观、药物研发景观、资金景观、治疗策略的演变以及SWOT分析。 关键点包括: 1. 2022年,全球GC新发病例约96.9万,死亡约66万,亚洲地区尤其是中国、日本和韩国的发病率较高。 2. 治疗指南推荐使用铂类化疗药物(如奥沙利铂)联合氟嘧啶类药物(如5-FU或卡培他滨)作为一线治疗,HER2阳性患者可加用曲妥珠单抗。 3. 2019年至今,全球启动了超过2000项GC临床试验,亚太地区、北美和欧洲为主要区域,中国和美国是主要试验国。 4. 药物研发方面,以抗HER2抗体(如曲妥珠单抗)和免疫检查点抑制剂(如派姆单抗、尼沃鲁单抗)为主。 5. 资金方面,非政府组织如癌症研究基金会和癌症研究协会为GC研究提供资金支持,2019-2023年,中国和美国在GC研究方面的风险投资领先。 6. 治疗策略方面,靶向治疗和免疫治疗(如PD-L1、MSI和HER2)为GC患者提供了个性化治疗选择。 7. SWOT分析指出,GC治疗在分子靶点识别和个性化治疗方面具有优势,但现有疗法在更广泛人群中的疗效有限,且成本高。
胃癌全球临床试验现状如何? 胃癌治疗有哪些新进展? 哪些药物对胃癌治疗有显著效果?
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