当前位置:首页 > 报告详情

EncoreSELECT-LIFE:一项非干预性随访研究旨在调查 SELECT 试验参与者中索玛鲁肽的长期疗效.pdf

上传人: 表表 编号:1279993 2026-07-18 1页 695.90KB

1、1Department of Internal Medicine,Division of Endocrinology and Peter O Donnell Jr.School of Public Health,University of Texas Southwestern Medical Center,Dallas,TX,USA;2Institute of Cardiovascular Science,University College London,London,UK;3Novo Nordisk A/S,Sborg,Denmark;4VA Puget Sound Health Care

2、 System and University of Washington,Seattle,WA,USA;5Department of Cardiovascular Medicine,Cleveland Clinic,and Cleveland Clinic Lerner College of Medicine,Case Western Reserve University School of Medicine,Cleveland,OH,USA;6Division of Cardiovascular Medicine,Brigham and Womens Hospital,Harvard Med

3、ical School,Boston,MA,USA;7Pennington Biomedical Research Center,Baton Rouge,LA,USA.ldiko Lingvay declares having received research funding(paid to institution)and/or product from Novo Nordisk,Boehringer-Ingelheim,Dexcom,Roche,Pfizer,Lilly.She has also received research related consulting fees,inclu

4、ding support for attending meeting and/or travel(paid to institution)from Novo Nordisk;and advisory/consulting fees and/or other support from AbbVie,Altimmune,Alveus Therapeutics,Amgen,Antag Therapeutics,AstraZeneca,Bain Capital,Bayer,Betagenon AB,Bioio Inc,Biomea,Boehringer Ingelheim,Carmot,Corxel,

5、Cytoki Pharma,Eli Lilly,Genentech,Intercept,Janssen/Johnson&Johnson,Juvena,Keros Therapeutic Inc,Mediflix,Merck,Metsera,Neurocrine,Novo Nordisk,Pfizer,Regeneron,Roche,Sanofi,Shionogi,Source Bio,Structure Therapeutics,TERNS Pharma,The Comm Group,Verdiva Bio,WebMD,and Zealand Pharma.Ildiko Lingvay par

6、ticipates on the JAEB Center for Health board.This study was funded by Novo Nordisk A/S and is registered with ClinicalTrials.gov(NCT04972721).Editorial and administrative support was provided by Roxanna Munir,PhD,of Apollo,OPEN Health Communications,and funded by Novo Nordisk A/S,in accordance with

word格式文档无特别注明外均可编辑修改,预览文件经过压缩,下载原文更清晰!
三个皮匠报告文库所有资源均是客户上传分享,仅供网友学习交流,未经上传用户书面授权,请勿作商用。
1. **研究目的**:评估停用司美格鲁肽后,其对超重/肥胖合并心血管疾病(无糖尿病)患者的长期影响(SELECT-LIFE研究)。 2. **核心数据**: - 3435名参与者(19.5%)入组,80.2%完成≥1次问卷。 - 历史司美格鲁肽组 vs. 安慰剂组:主要不良心血管事件(MACE)发生率相似(3.4% vs. 3.1%);新发T2D比例相近(1.5% vs. 1.2%)。 - 体重变化:司美格鲁肽组从87.6 kg增至91.4 kg,安慰剂组从96.0 kg降至93.5 kg。 - 司美格鲁肽组报告的癌症、膝关节置换术和CPAP启动率数值更低。 3. **结论**:未发现司美格鲁肽的"遗留效应",停药后体重部分回升,但T2D风险未增加。
**减肥药有“后劲”吗?** **停药后体重会反弹吗?** **心血管获益能持久吗?**
客服
商务合作
小程序
服务号
折叠